Prof. Metin Akay, Thayer School of Engineering Psychology and Brain Sciences, Dartmouth College
The biological sciences have become more quantitative and information-driven as a result of emerging computational and mathematical tools which facilitate collection and analysis of vast amounts of biological data. Complexity analysis of biological systems provides biological knowledge for the organization, management and mining of biological data by using advanced computational tools. The biological data are inherently complex and non-uniform and collected at multiple temporal and spatial scales. The investigations of complex biological systems and processes require an extensive use of computational tools to improve our understanding of complex biological processes from system to gene.
In this talk, we focus on the relatively new approaches to the mathematical and computational challenges in Integrative Neuroscience and the new directions in computational neuroscience and neural informatics; and, we discuss the ongoing research activities at the Neural Engineering and Informatics Lab at Dartmouth. Our main emphasis will be on our recent finding about the relative contributions of maturation to the dynamics of respiration patterns from system to single cell in the neonate. We define and quantify changes in the complexity of the respiratory neural network that accompany maturation in piglets using the approximate entropy method which provides a model independent measure of the complexity (irregularity) of the underlying mechanisms of the respiratory network.
Acknowledgements: This research was supported in part by NIH-65732.
Associate Professor of Engineering, Psycology and Brain Sciences, and Computer Science at Dartmouth. Prof. Akay has played a key role in promoting the biomedical education in the world by writing several prestigous books and editing the first biomedical engineering book series published by the Wiley and IEEE Press and sponsored by the IEEE EMB Society. The book series had 9 published books and 8 in press and several pending proposals.
Prof Akay is author/coauthor of the 12 books including "Theory and Design of Biomedical Instruments (Academic Press, 1991)", "Biomedical Signal Processing (Academic Press, 1994)", "Detection Estimation of Biomedical Signals(Academic Press, 1996)", "Time-Freq and Wavelets in BME (Wiley and IEEE Press, 1997)" Nonlinear Biomedical Signal Processing (Wiley and IEEE Press, 2000), Information Tech in Medicine (Wiley and Sons, 2000).
He is the founding and current editor-chief of the first online, interactive Biomedical Engineering and Science Encyclopedia published by the Wiley and sponsored with many international organizations.
He served as the invited guest editor for 12 special issues of the IEEE EMB Mag, Annals of BME, Journal of BME in the areas of cardiovascular engineering, Virtual Reality in Medicine, Advances in Biomedical Signal Processing, Fuzzy Logic in Medicine. He is also the invited guest editor for the Proc of IEEE, the second largely cited IEEE journal, on Neural Engineering. He is also the invited guest editor for the special issue of the Proc of IEEEE on the Funcational Genomics which will be published in 2002.
He was the chair of the IEEE EMBS Summer School 1997, 2001, 2002. He was also the program chair of the Annual IEEE EMBS Conference 2001. He gave 30 keynote and plenary talks and several invited talks at the international meetings including the ICAP'94, IFSA'95, the DSP applications and Exhibition Conference'96, the Satellite Symposium of the IEEE EMBS'98 in China, the 12th Annual Conference of Japanese Society of Medical Electronics and Biomedical Engineering, the first and second Latin-American Conference on Biomedical Engineering'98 and 01.
Prof. Akay is the YOUNGEST receipent of the prestigous IEEE EMBS Career Service "for his outstanding contributions to the advancement of the scientific stature and visibility of IEEE-EMBS and extraordinary dedication to the promotion of biomedical engineering education in the world." He is also the YOUNGEST receipent of the IEEE Third Millenium Medal for " his contributions to biomedical engineering research and education".
He was received the IEEE Engineering in Medicine and Biology Society Early Career Achievement Award 1997 "for outstanding contributions in the detection of coronary artery disease, in understanding of early human development, and leadership and contributions in biomedical engineering education".
Prof. Akay is the ONLY faculty who received the prestigous Young Investigator Award of the Sigma Xi Society, Northeast Region TWICE in 1998 and 200 for "his outstanding research activity and the ability to communicate the importance of his research to the general public. The Sigma Xi has more than 160 Nobel Laurate members and several National Academy members.
Prof. Akay is a strong supporters of the women and minorities in the engineering, medicine and science in the world. All these activities are supported by the NSF and largely attended by the women and minorities. He is also the IEEE Distinguished lecturer in Bioengineering.
Dr. Akay is a senior member of IEEE, a member of Eta Kappa, Sigma Xi, Tau Beta Pi, The American Heart Association, and The New York Academy of Science. He also serves on the advisory board of several international journals including the IEEE T-BME, IEEE ITIB, Smart Engineering Systems etc. and organizations and NIH Bioengineering partnership study session and several NSF review panels.
He has been very active in the biomedical engineering community and serve at the Bioengineering partnership NIH study session and several prestigous interdisciplinary NSF panels since 1990. He has played a major role in introducing the emerging technologies to the biomedical engineering community. He coined the term "neural engineering" and has played a key role in the biocomplexity and in promoting the world enhancement of biomedical informatics and bioengineering opportunities for women and minorities.
Dr. Akay's Neural Engineering and Informatics Lab is interested in investigating the respiratory somatosensory (RSS) responses of patients with obstructive sleep apnea syndrome (OSAS) and the effect of developmental abnormailities and maturation on the dynamics of respiration.
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